An iminosugar with potent inhibition of dengue virus infection in vivo.
Antiviral Res
; 98(1): 35-43, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-23376501
ABSTRACT
The aim of the present study was to evaluate the ability of the iminosugar drug UV-4 to provide in vivo protection from lethal dengue virus (DENV) challenge. This study utilized a well-described model of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS)-like lethal disease in AG129 mice lacking the type I and II interferon receptors. Herein, we present UV-4 as a potent iminosugar for controlling DENV infection and disease in this mouse model. Specifically, administration of UV-4 reduced mortality, as well as viremia and viral RNA in key tissues, and cytokine storm. In addition, UV-4 treatment can be delayed, and it does not alter the anti-DENV antibody response. These results have set the foundation for development of UV-4 as a DENV-specific antiviral in phase I human clinical trials.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Dengue
/
Virus del Dengue
/
Iminoazúcares
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Antiviral Res
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos