Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain people.
Trends Genet
; 29(7): 412-8, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23422049
ABSTRACT
The rapid development of next-generation sequencing (NGS) technology has led to renewed interest in the potential contribution of rarer forms of genetic variation to complex non-mendelian phenotypes such as psychiatric illnesses. Although challenging, family-based studies offer some advantages, especially in communities with large families and a limited number of founders. Here we revisit family-based studies of mental illnesses in traditional Amish and Mennonite communities--known collectively as the Plain people. We discuss the new opportunities for NGS in these populations, with particular emphasis on investigating psychiatric disorders. We also address some of the challenges facing NGS-based studies of complex phenotypes in founder populations.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Investigación Genética
/
Secuenciación de Nucleótidos de Alto Rendimiento
/
Amish
/
Trastornos Mentales
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Trends Genet
Asunto de la revista:
GENETICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos