Metabolic rates associated with membrane fatty acids in mice selected for increased maximal metabolic rate.
Comp Biochem Physiol A Mol Integr Physiol
; 165(1): 70-8, 2013 May.
Article
en En
| MEDLINE
| ID: mdl-23422919
ABSTRACT
Aerobic metabolism of vertebrates is linked to membrane fatty acid (FA) composition. Although the membrane pacemaker hypothesis posits that desaturation of FAs accounts for variation in resting or basal metabolic rate (BMR), little is known about the FA profiles that underpin variation in maximal metabolic rate (MMR). We examined membrane FA composition of liver and skeletal muscle in mice after seven generations of selection for increased MMR. In both liver and skeletal muscle, unsaturation index did not differ between control and high-MMR mice. We also examined membrane FA composition at the individual-level of variation. In liver, 180, 203 n-6, 204 n-6, and 226 n-3 FAs were significant predictors of MMR. In gastrocnemius muscle, 182 n-6, 204 n-6, and 226 n-3 FAs were significant predictors of MMR. In addition, muscle 161 n-7, 181 n-9, and 225 n-3 FAs were significant predictors of BMR, whereas no liver FAs were significant predictors of BMR. Our findings indicate that (i) individual variation in MMR and BMR appears to be linked to membrane FA composition in the skeletal muscle and liver, and (ii) FAs that differ between selected and control lines are involved in pathways that can affect MMR or BMR.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Metabolismo Basal
/
Metabolismo Energético
/
Ácidos Grasos
/
Membranas
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol A Mol Integr Physiol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
FISIOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos