Palladium-catalyzed carbonylative Sonogashira coupling of aryl bromides via tert-butyl isocyanide insertion.
J Org Chem
; 78(7): 3170-5, 2013 Apr 05.
Article
en En
| MEDLINE
| ID: mdl-23438012
ABSTRACT
A simple and efficient palladium-catalyzed carbonylative Sonogashira coupling via tert-butyl isocyanide insertion has been developed, which demonstrates the utility of isocyanides in intermolecular C-C bond construction. This methodology provides a novel pathway for the synthesis of alkynyl imines which can undergo simple silica gel catalyzed hydrolysis to afford alkynones. The approach is tolerant of a wide range of substrates and applicable to library synthesis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
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Paladio
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Bromuros
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Cetonas
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Nitrilos
Idioma:
En
Revista:
J Org Chem
Año:
2013
Tipo del documento:
Article