Maribavir inhibits Epstein-Barr virus transcription through the EBV protein kinase.
J Virol
; 87(9): 5311-5, 2013 May.
Article
en En
| MEDLINE
| ID: mdl-23449792
ABSTRACT
Maribavir (MBV) inhibits Epstein-Barr virus (EBV) replication and the enzymatic activity of the viral protein kinase BGLF4. MBV also inhibits expression of multiple EBV transcripts during EBV lytic infection. Here we demonstrate, with the use of a BGLF4 knockout virus, that effects of MBV on transcription take place primarily through inhibition of BGLF4. MBV inhibits viral genome copy numbers and infectivity to levels similar to and exceeding levels produced by BGLF4 knockout virus.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Ribonucleósidos
/
Proteínas Virales
/
Bencimidazoles
/
Regulación hacia Abajo
/
Regulación Viral de la Expresión Génica
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Proteínas Serina-Treonina Quinasas
/
Herpesvirus Humano 4
/
Infecciones por Virus de Epstein-Barr
Límite:
Humans
Idioma:
En
Revista:
J Virol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos