Polymorphisms of paraoxonase 1 and 2 genes and the risk of multiple sclerosis in the Polish population.

ABSTRACT

BACKGROUND AND PURPOSE: The aim of this study was to test the hypothesis that polymorphisms of the paraoxonase genes PON1 and PON2 may be associated with increased risk of developing multiple sclerosis (MS) in the Polish population. MATERIAL AND METHODS: We studied the significance of the PON gene polymorphisms C311S, A162G, Q192R and L55M in 221 patients (including 145 women) with MS and in 661 healthy controls. In the MS population, mean Expanded Disability Status Scale score was 2.92, mean age was 36.8 years, and mean disease duration was 7.7 years. PON genotyping was determined using polymerase chain reaction and restriction enzyme digestion. RESULTS: According to our results, the PON1 and PON2 genotypes distribution did not differ between the MS patients and the controls. CONCLUSIONS: The polymorphisms of the PON genes studied are not related to increased risk of MS in the Polish population.