X-ray fluorescence tomographic system design and image reconstruction.
J Xray Sci Technol
; 21(1): 1-8, 2013.
Article
en En
| MEDLINE
| ID: mdl-23507848
ABSTRACT
In this paper, we presented a new design of x-ray fluorescence CT imaging system. For detecting fuorescence signals of gold nanoparticles in-vivo, multiple spectroscopic detectors are arranged and rotated orthogonal to an excited region of interest so that a localized scan can be acquired with a maximized efficiency. Excitation filtration was employed to minimize the effects of low-energy x-rays and background scattering for lowering radiation dose to the object. Numerical simulations showed that the radiation dose is less than 300 mGy/second for a complete 30 views tomographic scan; and the sensitivity of 3D fluorescence signal detection is up to 0.2% contrast concentrations of nanoparticles. The x-ray fluorescence computed tomography is an important molecular imaging tool. It can be used directly in samall animal research. It has great translational potential for future clinical applications.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Procesamiento de Imagen Asistido por Computador
/
Tomografía Computarizada por Rayos X
/
Imagen Óptica
Idioma:
En
Revista:
J Xray Sci Technol
Asunto de la revista:
RADIOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos