Protective effect of Coleus aromaticus Benth (Lamiaceae) against naphthalene-induced hepatotoxicity.
Biomed Environ Sci
; 26(4): 295-302, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-23534470
ABSTRACT
OBJECTIVE:
To investigate protective effect of Coleus aromaticus leaf extract against naphthalene induced hepatotoxicity in rats.METHODS:
Eighteen male rats were divided into three groups. Group I rats were treated as control. Group II rats were intraperitoneally administered with naphthalene (435 mg/kg b.wt) dissolved in corn oil once a day for a period of 30 days. Group III rats were treated with leaf extract (100 mg/kg b.wt) dissolved in 0.9% saline and naphthalene (435 mg/kg b.wt) dissolved in corn oil once a day for a period of 30 days.RESULTS:
Significant protective effect was observed against naphthalene induced liver damage, which appeared evident from the response levels of marker enzymes (aspartate transaminase, alanine transaminase, acid phosphatase, alkaline phosphatase and lactate dehydrogenase). The biochemical components viz. triglycerides, free fatty acids, cholesterol acyl transferase, high-density lipoprotein, low-density lipoprotein, cholesterol and bilirubin were found to be increased in liver and serum of naphthalene stressed rats when compared to control.CONCLUSION:
Treatment of naphthalene intoxicated rats with plant extract reversed these distorted parameters to near normal levels. Liver histology showed supportive evidence regarding the protective nature of plant extract against fatty changes induced by naphthalene. The present study provides a scientific rationale for using C. aromaticus in the management of liver disorders.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Coleus
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Fitoterapia
/
Naftalenos
Límite:
Animals
Idioma:
En
Revista:
Biomed Environ Sci
Asunto de la revista:
SAUDE AMBIENTAL
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos