The association of selective serotonin reuptake inhibitors use and stroke in geriatric population.
Am J Geriatr Psychiatry
; 21(8): 811-5, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23567390
ABSTRACT
OBJECTIVES:
Selective serotonin reuptake inhibitor (SSRI) exposure has controversial results in increasing the stroke risk. With the risk of stroke increased with age, the safety of SSRI use among older adults attracts much concern.METHODS:
We analyzed 28,145 subjects older than 65 years from a subset of a 9-year cohort database from the National Health Insurance Research Database, Taiwan.RESULTS:
The survival analysis showed a greater probability of stroke in subjects with SSRI exposure after adjusting other covariates. Compared with other variables, SSRI exposure had the strongest effect (hazard ratio 2.66, 95% confidence interval 2.21-3.20). The risk was independent to depression-related stroke risk.CONCLUSIONS:
The use of SSRIs independently increases the risk of stroke among older patients. SSRIs are still practically safe to most users, providing precautionary measures are taken.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Inhibidores Selectivos de la Recaptación de Serotonina
/
Accidente Cerebrovascular
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Am J Geriatr Psychiatry
Asunto de la revista:
GERIATRIA
/
PSIQUIATRIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Taiwán