Cromatina/metabolismo; Daño del ADN; Inestabilidad Genómica; Células de Purkinje/metabolismo; Animales; Proteínas de la Ataxia Telangiectasia Mutada/genética; Proteínas de la Ataxia Telangiectasia Mutada/metabolismo; Cromatina/genética; Cromatina/patología; Homólogo de la Proteína Chromobox 5; Humanos; Ratones; Ratones Noqueados; Células de Purkinje/patología; Técnicas de Cultivo de Tejidos

53BP1; A-T; A-TLD; AOA1/2; ATM; ATM- and Rad3-related protein kinase; ATR; Ataxia-telangiectasia; CaBP; Cerebellar organotypic cultures; Chromatin; DDR; DNA damage response; DNA dependent protein kinase, catalytic subunit; DNA-PKcs; DSB; GFAP; H2AX; H3K9Me3; HDR; HP1α; HR; MRN complex; Mre11; Mre11/Rad50/Nbs1 complex; NBS; NHEJ; NLC; NeuN; Nijmegen breakage syndrome; PI3K; PIK-related kinases; SCAN1; ataxia with oculomotor apraxia type 1; ataxia-telangiectasia; ataxia-telangiectasia, mutated; ataxia-telangiectasia-like disorder/disease; calbindin protein (calbindin-D28K); double strand break; glial fibrillary acidic protein; heterochromatin protein 1alpha; histone 2AX; homologues recombination; homology-directed repair; iPS cells; induced pluripotent stem cells; meiotic recombination 11; neuron-like cell; neuronal nucleus; nonhomologues end-joining; p53 binding protein 1; phosphatidyl inositol kinase-related protein kinases; phosphatidylinositol 3- kinase; phosphorylated histone 2AX; spinocerebellar ataxia with axonal neuropathy; trimethylated lysine 9 of histone 3; γH2AX