Biodegradable weft-knitted intestinal stents: fabrication and physical changes investigation in vitro degradation.
J Biomed Mater Res A
; 102(4): 982-90, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-23625859
ABSTRACT
Biodegradable stents can alleviate intestinal obstruction and stenosis in patients. The objective of this study was to develop a biodegradable polydioxanone (PDO) stent using weft-knitting technology and then investigate its biodegradation behaviors in vitro. PDO monofilament with linear density of 100 ± 10 tex was knitted into a tubular stent using a tubular weft-knitting machine. The physical and mechanical properties were evaluated according to the British standard BS EN 138952003 and ISO 71981998. The biodegradation behaviors of PDO weft-knitted stent in a phosphate buffer solution (pH = 6.8 ± 0.2, 37 ± 0.5 °C) were then investigated. The results showed that the stent maintained more than 60% of its original radial force above 12 weeks. During the 16 weeks of degradation, weight, crystallization, and pH change indicated the degradation medium was diffused into the chain segments of low molecular weight due to the rupture of ester bonds in the monofilament. Fourier transform infrared spectroscopy results demonstrated that the chemical structure of PDO polymer is stable during the in vitro degradation. In conclusion, this biodegradable stent can find valuable applications in treatment of intestinal obstruction and stenosis clinically.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Materiales Biocompatibles
/
Ensayo de Materiales
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Stents
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Implantes Absorbibles
/
Intestinos
Idioma:
En
Revista:
J Biomed Mater Res A
Asunto de la revista:
ENGENHARIA BIOMEDICA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Hong Kong