Gender-specific differences in clinical outcome of primary prevention implantable cardioverter defibrillator recipients.
Heart
; 99(17): 1244-9, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-23723448
ABSTRACT
OBJECTIVE:
To assess differences in clinical outcome of implantable cardioverter-defibrillator (ICD) treatment in men and women.DESIGN:
Prospective cohort study.SETTING:
University Medical Center. PATIENTS 1946 primary prevention ICD recipients (1528 (79%) men and 418 (21%) women). Patients with congenital heart disease were excluded for this analysis. MAIN OUTCOMEMEASURES:
All-cause mortality, ICD therapy (antitachycardia pacing and shock) and ICD shock.RESULTS:
During a median follow-up of 3.3 years (25th-75th percentile 1.4-5.4), 387 (25%) men and 76 (18%) women died. The estimated 5-year cumulative incidence for all-cause mortality was 20% (95% CI 18% to 23%) for men and 14% (95% CI 9% to 19%) for women (log rank p<0.01). After adjustment for potential confounding covariates all-cause mortality was lower in women (HR 0.65; 95% CI 0.49 to 0.84; p<0.01). The 5-year cumulative incidence for appropriate therapy in men was 24% (95% CI 21% to 28%) as compared with 20% (95% CI 14% to 26%) in women (log rank p=0.07). After adjustment, a non-significant trend remained (HR 0.82; 95% CI 0.64 to 1.06; p=0.13).CONCLUSIONS:
In clinical practice, 21% of primary prevention ICD recipients are women. Women have lower mortality and tend to experience less appropriate ICD therapy as compared with their male peers.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Arritmias Cardíacas
/
Enfermedad de la Arteria Coronaria
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Muerte Súbita Cardíaca
/
Desfibriladores Implantables
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Heart
Asunto de la revista:
CARDIOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Países Bajos