Synthesis, structure-property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor.
Eur J Med Chem
; 65: 360-75, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23747805
Palabras clave
1-hydroxybenzotriazole; 2,2,2-trichloroethyl chloroformate; 2-morpholinoethanesulphonic acid monohydrate; 3-amino-azetidinyl; 3-aze; 4-amino-piperidinyl; 4-dimethylamino-pyridine; 4-pip; Anti-platelet; CDI; CLint; Caco-2; DIPEA; DMA; DMAP; DSC; EDCI; GTPγS; HLM; HOBT; LC; MES; MW; N,N-diisopropylethylamine; N,N'-carbonyl diimidazole; N,N'-disuccinimide carbonate; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; P2Y(12) receptor; PS; RLM; Solubility; Stability; Sulfonylureas; TEA; TEER; TEG; Troc-Cl; WPA; adenocarcinoma cells from human colon; cy-Pr; cyclopropyl; dimethylacetamide; guanosine 5'-O-[γ-thio]triphosphate; human liver microsomes; intrinsic clearance; liquid chromatography; paz; piperazinyl; polymer-supported; rat liver microsomes; room temperature; rt; single node heating in a microwave oven; transepithelial electrical resistance; triethylamine; triethyleneglycol; washed platelet assay
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Urea
/
Receptores Purinérgicos P2Y12
/
Antagonistas del Receptor Purinérgico P2Y
/
Ácidos Nicotínicos
Límite:
Animals
Idioma:
En
Revista:
Eur J Med Chem
Año:
2013
Tipo del documento:
Article
País de afiliación:
Suecia