Structures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55.

Li, Xiang; Zvanych, Rostyslav; Torchia, Jonathon; Magarvey, Nathan A

Li, Xiang; Zvanych, Rostyslav; Torchia, Jonathon; Magarvey, Nathan A.

Afiliación

Li X; Department of Biochemistry and Biomedical Sciences, M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

Bioorg Med Chem Lett ; 23(14): 4150-3, 2013 Jul 15.

Article en En | MEDLINE | ID: mdl-23756369

ABSTRACT

ABSTRACT

Two novel depsipeptides (1-2) were isolated from Streptomyces sp. ML55 together with two known analogues (3-4). Their structures were elucidated using a combination of NMR experiments, as well as detailed MS/MS experiments. The biosynthetic pathway of isolated compounds was dissected by genome sequencing data analysis for a hybrid nonribosomal peptide synthetase (NRPS) and polyketide synthetase (PKS) assembly line.

Asunto(s)

Depsipéptidos/biosíntesis; Streptomyces/metabolismo; Proliferación Celular/efectos de los fármacos; Depsipéptidos/química; Depsipéptidos/toxicidad; Células HT29; Humanos; Espectroscopía de Resonancia Magnética; Conformación Molecular; Familia de Multigenes; Péptido Sintasas/metabolismo; Streptomyces/genética; Espectrometría de Masas en Tándem

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Streptomyces / Depsipéptidos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2013 Tipo del documento: Article País de afiliación: Canadá

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