Efficient enantioselective total synthesis of (-)-horsfiline.
Chemistry
; 19(29): 9599-605, 2013 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-23836402
ABSTRACT
A new efficient and concise enantioselective synthetic method for (-)-horsfiline is reported. (-)-Horsfiline could be obtained from diphenylmethyl tert-butyl malonate in 9 steps (32%,>99% ee) by using the enantioselective phase-transfer catalytic allylation (91% ee) as the key step. This approach can be applied as a practical route for the large-scale synthesis of spirooxindole natural products, which enables a systematic investigation of their biological activity to be performed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Compuestos de Espiro
/
Productos Biológicos
/
Malonatos
Idioma:
En
Revista:
Chemistry
Asunto de la revista:
QUIMICA
Año:
2013
Tipo del documento:
Article