Platinum compounds and sodium metabolism in children with diencephalic glioma.
J Neurooncol
; 115(1): 113-7, 2013 Oct.
Article
en En
| MEDLINE
| ID: mdl-23839227
ABSTRACT
In this brief report we have described eight children affected by optic pathway/hypothalamus gliomas and treated with carboplatin and/or cisplatin, which developed a derangement of sodium and water metabolism, due to diabetes insipidus (DI) or to syndrome of inappropriate antidiuretic hormone secretion (SIADH) after surgical resection. In four out of these eight patients the treatment with platinum compounds produced prolonged haematological toxicity and in five out of them it caused neurosensorial bilateral hypoacusia. In addition cisplatin worsened electrolytes disturbances. Hence children with DI or SIADH should be carefully monitored before, during and after the treatment with platinum compounds.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sodio
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Desequilibrio Hidroelectrolítico
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Neoplasias Encefálicas
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Protocolos de Quimioterapia Combinada Antineoplásica
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Diabetes Insípida
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Glioma
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Síndrome de Secreción Inadecuada de ADH
Tipo de estudio:
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
J Neurooncol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia