Vaccines against meningococcal serogroup B disease containing outer membrane vesicles (OMV): lessons from past programs and implications for the future.
Hum Vaccin Immunother
; 9(6): 1241-53, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-23857274
ABSTRACT
The utility of wild-type outer membrane vesicle (wtOMV) vaccines against serogroup B (MenB) meningococcal disease has been explored since the 1970s. Public health interventions in Cuba, Norway and New Zealand have demonstrated that these protein-based vaccines can prevent MenB disease. Data from large clinical studies and retrospective statistical analyses in New Zealand give effectiveness estimates of at least 70%. A consistent pattern of moderately reactogenic and safe vaccines has been seen with the use of approximately 60 million doses of three different wtOMV vaccine formulations. The key limitation of conventional wtOMV vaccines is their lack of broad protective activity against the large diversity of MenB strains circulating globally. The public health intervention in New Zealand (between 2004-2008) when MeNZB was used to control a clonal MenB epidemic, provided a number of new insights regarding international and public-private collaboration, vaccine safety surveillance, vaccine effectiveness estimates and communication to the public. The experience with wtOMV vaccines also provide important information for the next generation of MenB vaccines designed to give more comprehensive protection against multiple strains.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vacunas Meningococicas
/
Neisseria meningitidis Serogrupo B
/
Micropartículas Derivadas de Células
/
Infecciones Meningocócicas
Límite:
Humans
País/Región como asunto:
Caribe
/
Cuba
/
Europa
/
Oceania
Idioma:
En
Revista:
Hum Vaccin Immunother
Año:
2013
Tipo del documento:
Article
País de afiliación:
Noruega