The cost of sensitive response and accurate adaptation in networks with an incoherent type-1 feed-forward loop.
J R Soc Interface
; 10(87): 20130489, 2013 Oct 06.
Article
en En
| MEDLINE
| ID: mdl-23883955
ABSTRACT
The incoherent type-1 feed-forward loop (I1-FFL) is ubiquitous in biological regulatory circuits. Although much is known about the functions of the I1-FFL motif, the energy cost incurred in the network and how it affects the performance of the network have not been investigated. Here, we study a generic I1-FFL enzymatic reaction network modelled after the GEF-GAP-Ras pathway responsible for chemosensory adaptation in eukaryotic cells. Our analysis shows that the I1-FFL network always operates out of equilibrium. Continuous energy dissipation is necessary to drive an internal phosphorylation-dephosphorylation cycle that is crucial in achieving strong short-time response and accurate long-time adaptation. In particular, we show quantitatively that the energy dissipated in the I1-FFL network is used (i) to increase the system's initial response to the input signals; (ii) to enhance the adaptation accuracy at steady state; and (iii) to expand the range of such accurate adaptation. Moreover, we find that the energy dissipation rate, the catalytic speed and the maximum adaptation accuracy in the I1-FFL network satisfy the same energy-speed-accuracy relationship as in the negative-feedback-loop (NFL) networks. Because the I1-FFL and NFL are the only two basic network motifs that enable accurate adaptation, our results suggest that a universal cost-performance trade-off principle may underlie all cellular adaptation processes independent of the detailed biochemical circuit architecture.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas ras
/
Proteínas Activadoras de GTPasa
/
Factores de Intercambio de Guanina Nucleótido
/
Modelos Biológicos
Tipo de estudio:
Diagnostic_studies
/
Health_economic_evaluation
/
Prognostic_studies
Idioma:
En
Revista:
J R Soc Interface
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos