An examination of the mutual effects of valproic acid, carbamazepine, and phenobarbital on 25-hydroxyvitamin D levels and thyroid function tests.
Neuropediatrics
; 45(1): 16-21, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-23888467
ABSTRACT
BACKGROUND:
The effects of antiepileptic drugs (AEDs) on bone metabolism and the endocrine system are not fully known, and publications on the subject are inconsistent.OBJECTIVE:
The study aimed to examine the mutual effects of valproic acid (VPA), carbamazepine (CBZ), and phenobarbital (PB)-AEDs frequently used in childhood-on bone mineral metabolism and thyroid function tests. PATIENTS ANDMETHODS:
Children monitored with a diagnosis of idiopathic epilepsy by the pediatric neurology clinic, using AEDs for at least 6 months and with episodes under control, were included in the study. Patients were divided into groups on the basis of the drugs used. Thyroid function tests and 25-hydroxyvitamin D or 25(OH)D levels were measured from blood specimens. The data obtained were then compared with those of the control group.RESULTS:
A significantly high level of subclinical hypothyroidism was seen in patients using VPA (p < 0.001). There was no significant difference between any of the three study groups and the control group in terms of 25(OH)D (p > 0.05).CONCLUSIONS:
Pediatric patients using AEDs, particularly VPA, should be monitored for subclinical hypothyroidism. VPA, CBZ, and PB have no effect on vitamin D levels.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fenobarbital
/
Vitamina D
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Carbamazepina
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Ácido Valproico
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Anticonvulsivantes
Límite:
Child
/
Female
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Humans
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Male
Idioma:
En
Revista:
Neuropediatrics
Año:
2014
Tipo del documento:
Article
País de afiliación:
Turquía