Seroreactivity to Plasmodium falciparum erythrocyte membrane protein 1 intracellular domain in malaria-exposed children and adults.
J Infect Dis
; 208(9): 1514-9, 2013 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-23901079
ABSTRACT
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens mediate parasite sequestration and host immune evasion. Reactivity to 21 PfEMP1 fragments on a protein microarray was measured in serum samples from Malian children aged 1-6 years and adults. Seroreactivity to PfEMP1 fragments was higher in adults than in children; intracellular conserved fragments were more widely recognized than were extracellular hypervariable fragments. Over a malaria season, children maintained this differential seroreactivity and recognized additional intracellular PfEMP1 fragments. This approach has the potential to identify conserved, seroreactive extracellular PfEMP1 domains critical for protective immunity to malaria.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Proteínas Protozoarias
/
Malaria Falciparum
/
Antígenos de Protozoos
Tipo de estudio:
Observational_studies
Límite:
Adult
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Child
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Child, preschool
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Humans
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Infant
Idioma:
En
Revista:
J Infect Dis
Año:
2013
Tipo del documento:
Article