Chlorine and sodium chemical shift imaging during acute stroke in a rat model at 9.4 Tesla.
MAGMA
; 27(1): 71-9, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-23934160
ABSTRACT
OBJECT A triple-resonant coil setup with an (1)H linear resonator and a double-tuned (23)Na/(35)Cl surface coil was used to study the evolution of T 2 (*) and M 0 for (35)Cl and (23)Na in a rat stroke model during the acute phase at 9.4 Tesla. MATERIALS AND METHODS:
In vivo measurements were performed 1.5-7 h after onset of stroke (n = 2), ten days after onset (n = 1) and on a healthy control rat by a chemical shift imaging sequence. Measurement times were 15 min ((23)Na) and 57 min ((35)Cl).RESULTS:
The relaxation times ten days after onset [T 2 (*) = 14.3 ± 1.8 ms ((23)Na) and 6.0 ± 1.3 ms ((35)Cl)] are clearly prolonged in comparison to a healthy rat [T 2 (*) = 4.8 ± 0.6 ms ((23)Na) and 2.1 ± 0.3 ms ((35)Cl)] and the acute phase [T 2 (*) = 5.6 ± 0.2 ms ((23)Na) and 1.9 ± 0.1 ms ((35)Cl)].CONCLUSION:
M 0 in the infarcted region clearly rises later and slower for chlorine than for sodium. To the best of our knowledge, these are the first combined proton, sodium, and chlorine measurements in an animal stroke model during the acute phase.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sodio
/
Imagen por Resonancia Magnética
/
Cloro
/
Accidente Cerebrovascular
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
MAGMA
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2014
Tipo del documento:
Article