Impact of mTOR-I on fertility and pregnancy: state of the art and review of the literature.
Expert Rev Clin Immunol
; 9(8): 781-9, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23971756
ABSTRACT
Successful transplantation should lead to improvements in sexual function and sex hormone disturbances in both men and women, but immunosuppressive drugs may interfere with hormone metabolism. In this regard, several studies have showed a potential negative effect of mTOR inhibitors (mTORi) on male gonadal function, while their role in the female patients is not well documented in the literature. Successful pregnancy is possible after solid organ transplantation. The fetal effects of mTORi are still poorly defined but they seem not to represent an absolute contraindication for pregnancy. The aim of our study would be to review the impact of mTORi on fertility and pregnancy in order to have a clearer picture about their possible use after organ transplantation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Posoperatorias
/
Complicaciones del Embarazo
/
Trasplante de Órganos
/
Sirolimus
/
Serina-Treonina Quinasas TOR
/
Rechazo de Injerto
/
Inmunosupresores
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Revista:
Expert Rev Clin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia