Computational models of the JAK1/2-STAT1 signaling.
JAKSTAT
; 2(3): e24672, 2013 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-24069559
ABSTRACT
Despite a conceptually simple mechanism of signaling, the JAK-STAT pathway exhibits considerable behavioral complexity. Computational pathway models are tools to investigate in detail signaling process. They integrate well with experimental studies, helping to explain molecular dynamics and to state new hypotheses, most often about the structure of interactions. A relatively small amount of experimental data is available for a JAK1/2-STAT1 variant of the pathway, hence, only several computational models were developed. Here we review a dominant approach of kinetic modeling of the JAK1/2-STAT1 pathway, based on ordinary differential equations. We also give a brief overview of attempts to computationally infer topology of this pathway.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
JAKSTAT
Año:
2013
Tipo del documento:
Article
País de afiliación:
Polonia