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Targeted deep resequencing identifies MID2 mutation for X-linked intellectual disability with varied disease severity in a large kindred from India.
Geetha, Thenral S; Michealraj, Kulandaimanuvel Antony; Kabra, Madhulika; Kaur, Gurjit; Juyal, Ramesh C; Thelma, B K.
Afiliación
  • Geetha TS; Department of Genetics, University of Delhi South Campus, New Delhi, India.
Hum Mutat ; 35(1): 41-4, 2014 Jan.
Article en En | MEDLINE | ID: mdl-24115387
We report a novel missense mutation (c.1040G>A, p.Arg347Gln) in MID2, which encodes ubiquitin ligase E3, as the likely cause of X-linked mental retardation in a large kindred. The mutation was observed in all affected and obligate carriers but not in any unaffected males of the family or in population controls (n = 200). When transiently expressed in HEK293T cell line, the mutation was found to abolish the function of the COS domain in the protein. The GFP-tagged mutant protein accumulated in the cytoplasm instead of binding to the cytoskeleton resulting in its altered subcellular localization. Screening of coding exons of this gene in additional 480 unrelated individuals with idiopathic intellectual disability identified another novel variation p.Asn343Ser. This study highlights the growing role of the ubiquitin pathway in intellectual disability and also, the difference in MID2 determined phenotype observed in this study compared with that of its paralogue MID1 reported in literature.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Discapacidad Intelectual Ligada al Cromosoma X / Secuenciación de Nucleótidos de Alto Rendimiento / Proteínas Asociadas a Microtúbulos Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Hum Mutat Asunto de la revista: GENETICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Discapacidad Intelectual Ligada al Cromosoma X / Secuenciación de Nucleótidos de Alto Rendimiento / Proteínas Asociadas a Microtúbulos Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Hum Mutat Asunto de la revista: GENETICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: India