Fluorescent conjugate of sLe(x)-selective bisboronic acid for imaging application.
Bioorg Med Chem Lett
; 23(23): 6307-9, 2013 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-24125887
ABSTRACT
Carbohydrate-based biomarkers such as sialyl Lewis X are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed a boronolectin-fluorophore conjugate, which was able to selectively label and image xenograft (sc) tumor. This represents the very first example that a small molecule capable of recognizing a carbohydrate biomarker was used for optical imaging application.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Compuestos de Boro
/
Antígeno Lewis X
/
Imagen Óptica
/
Colorantes Fluorescentes
/
Monosacáridos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2013
Tipo del documento:
Article