Mutation of TP53 and alteration of p14(arf) expression in EGFR- and KRAS-mutated lung adenocarcinomas.

Cortot, Alexis B; Younes, Mohamad; Martel-Planche, Ghislaine; Guibert, Benoit; Isaac, Sylvie; Souquet, Pierre-Jean; Commo, Frédéric; Girard, Philippe; Fouret, Pierre; Brambilla, Elisabeth; Hainaut, Pierre; Soria, Jean-Charles

Cortot, Alexis B; Younes, Mohamad; Martel-Planche, Ghislaine; Guibert, Benoit; Isaac, Sylvie; Souquet, Pierre-Jean; Commo, Frédéric; Girard, Philippe; Fouret, Pierre; Brambilla, Elisabeth; Hainaut, Pierre; Soria, Jean-Charles.

Afiliación

Cortot AB; International Agency for Research on Cancer, Lyon, France; Department of Thoracic Oncology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France; Thoracic Oncology Department, Lille University Hospital, Université Lille Nord de France, Lille, France. Electronic address: alexis
Younes M; International Agency for Research on Cancer, Lyon, France; Clinical Research Unit and Department of Pharmacology, Saint-Antoine University of Medicine, University Pierre et Marie Curie Paris 6, Paris, France.
Martel-Planche G; International Agency for Research on Cancer, Lyon, France.
Guibert B; Department of Thoracic Oncology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
Isaac S; Department of Pathology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
Souquet PJ; Department of Thoracic Oncology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
Commo F; Department of Translational Research, Institut Gustave Roussy, Villejuif, France; INSERM Unit 981, University Paris-South, France.
Girard P; Thorax Department, Institut Mutualiste Montsouris, Paris, France.
Fouret P; Department of Pathology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France; Department of Pathology, Institut Gustave Roussy, Villejuif, France.
Brambilla E; Institut Albert Bonniot, INSERM U823 and Department of Pathology, Hôpital Albert Michallon, Grenoble, France.
Hainaut P; International Agency for Research on Cancer, Lyon, France; International Prevention Research Institute, Lyon, France.
Soria JC; Department of Translational Research, Institut Gustave Roussy, Villejuif, France; INSERM Unit 981, University Paris-South, France.

Clin Lung Cancer ; 15(2): 124-30, 2014 Mar.

Article en En | MEDLINE | ID: mdl-24169260

Asunto(s)

Receptores ErbB/genética; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/metabolismo; Mutación/genética; Proteínas Proto-Oncogénicas/genética; Proteína p14ARF Supresora de Tumor/metabolismo; Proteína p53 Supresora de Tumor/genética; Proteínas ras/genética; Adenocarcinoma/genética; Adenocarcinoma/metabolismo; Adenocarcinoma/patología; Anciano; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Femenino; Estudios de Seguimiento; Humanos; Técnicas para Inmunoenzimas; Neoplasias Pulmonares/patología; Masculino; Persona de Mediana Edad; Estadificación de Neoplasias; Reacción en Cadena de la Polimerasa; Pronóstico; Proteínas Proto-Oncogénicas p21(ras); Estudios Retrospectivos; Transducción de Señal

Palabras clave

EGFR; KRAS; Lung adenocarcinoma; p14(arf); p53

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Proteínas Proto-Oncogénicas / Proteínas ras / Proteína p14ARF Supresora de Tumor / Receptores ErbB / Neoplasias Pulmonares / Mutación Tipo de estudio: Observational_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Lung Cancer Asunto de la revista: NEOPLASIAS Año: 2014 Tipo del documento: Article

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