Retinoblastoma: geographic distribution and presentation at a tertiary eye care centre in Kathmandu, Nepal.
Nepal J Ophthalmol
; 5(2): 169-76, 2013.
Article
en En
| MEDLINE
| ID: mdl-24172550
ABSTRACT
INTRODUCTION:
Several aspects of retinoblastoma in Nepal remain enigmatic.OBJECTIVE:
To assess the demographic and geographic distribution, clinical presentation, and treatment methods of retinoblastoma at a tertiary level ophthalmic institution in Kathmandu, Nepal. MATERIALS ANDMETHODS:
A retrospective analysis of all the patients diagnosed with retinoblastoma at Tilganga Institute of Ophthalmology from July 2004 to June 2008 was performed. The main outcome measures included region of residence, treatment options and histopathological findings. The histopathological analysis was performed on enucleated and exenterated specimens. STATISTICS The statistical analysis was performed with SPSS Version 11.5. Descriptive statistics are represented as mean ± standard deviation. All tests were two-sided and the P-values of less than 0.05 were considered statistically significant.RESULTS:
Thirty patients presented with retinoblastoma during the study period. The mean age at presentation was 2.5 ± 1.6 years (range five months to seven years). Ten of the 12 patients who presented with bilateral retinoblastoma (83 %) were from the Terai region of Nepal. The ratio of unilateral to bilateral cases in the Terai region was 12. This differed significantly with the ratio in the hilly region (Fisher's Exact Test, p = 0.0012). The mean duration of symptoms before presentation was 2.5 3.2 months (range three days to 12 months). Twenty-four patients (80 %) presented with leukocoria. Eleven patients (36.6 %) presented with leukocoria as their only symptom. Ninety-seven percent of the patients underwent either enucleation (90 %) or exenteration (6.7 %) of at least one eye.CONCLUSION:
Bilateral retinoblastoma is more prevalent in the Terai region of Nepal. The majority of the patients present with leucokoria and are treated with enucleation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Retinoblastoma
/
Enucleación del Ojo
/
Neoplasias de la Retina
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Quimioradioterapia
/
Centros de Atención Terciaria
/
Fotocoagulación
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Child, preschool
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Female
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Humans
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Infant
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Nepal J Ophthalmol
Asunto de la revista:
OFTALMOLOGIA
Año:
2013
Tipo del documento:
Article