The effect of Amaryllidaceae alkaloids haemanthamine and haemanthidine on cell cycle progression and apoptosis in p53-negative human leukemic Jurkat cells.

Havelek, Radim; Seifrtova, Martina; Kralovec, Karel; Bruckova, Lenka; Cahlikova, Lucie; Dalecka, Marketa; Vavrova, Jirina; Rezacova, Martina; Opletal, Lubomir; Bilkova, Zuzana

Havelek, Radim; Seifrtova, Martina; Kralovec, Karel; Bruckova, Lenka; Cahlikova, Lucie; Dalecka, Marketa; Vavrova, Jirina; Rezacova, Martina; Opletal, Lubomir; Bilkova, Zuzana.

Afiliación

Havelek R; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice 532 10, Czech Republic. Electronic address: radim.havelek@upce.cz.
Seifrtova M; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870, Hradec Kralove 500 38, Czech Republic.
Kralovec K; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice 532 10, Czech Republic.
Bruckova L; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice 532 10, Czech Republic.
Cahlikova L; ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University in Prague, Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic.
Dalecka M; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice 532 10, Czech Republic.
Vavrova J; Department of Radiobiology, Faculty of Military Health Sciences, University of Defense Brno, Trebesska 1575, Hradec Kralove 500 01, Czech Republic.
Rezacova M; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870, Hradec Kralove 500 38, Czech Republic.
Opletal L; ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University in Prague, Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic.
Bilkova Z; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice 532 10, Czech Republic.

Phytomedicine ; 21(4): 479-90, 2014 Mar 15.

Article en En | MEDLINE | ID: mdl-24182986

Asunto(s)

Alcaloides de Amaryllidaceae/uso terapéutico; Antineoplásicos Fitogénicos/análisis; Leucemia/tratamiento farmacológico; Liliaceae/química; Fenantridinas/uso terapéutico; Fitoterapia; Alcaloides de Amaryllidaceae/farmacología; Apoptosis/efectos de los fármacos; Caspasas/metabolismo; Puntos de Control del Ciclo Celular/efectos de los fármacos; Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1); Inhibidor p16 de la Quinasa Dependiente de Ciclina/metabolismo; Ensayos de Selección de Medicamentos Antitumorales; Genes p53; Humanos; Células Jurkat; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Fenantridinas/farmacología; Extractos Vegetales/farmacología; Extractos Vegetales/uso terapéutico; Proteínas Quinasas/metabolismo

Palabras clave

Apoptosis; Caspases; Cell cycle; Haemanthamine; Haemanthidine; Jurkat

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fenantridinas / Leucemia / Liliaceae / Alcaloides de Amaryllidaceae / Fitoterapia / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2014 Tipo del documento: Article

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