Naringin accelerates the regression of pre-neoplastic lesions and the colorectal structural reorganization in a murine model of chemical carcinogenesis.
Food Chem Toxicol
; 64: 200-9, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24296135
ABSTRACT
The aim of this study was to investigate the effect of Naringin on pre-neoplastic colorectal lesions induced by chemical carcinogen in rats. Female Wistar rats weighing 130.8±27.1 g received weekly one subcutaneous injection of 1,2-dimethylhydrazine (DMH, 20 mg/kg) for 10 weeks. The animals were divided into 5 groups with 6 animals in each group. Group 1 0.9% saline; Group 2 DMH+0.9% saline; Group 3 DMH+Naringin (10 mg/kg); Group 4 DMH+Naringin (100 mg/kg); Group 5 DMH+Naringin (200 mg/kg). G2 and G3 showed a significant increase in ACF number, AgNOR/nucleus and mitosis compared to G1. G4 and G5 presented a significant reduction in these parameters compared to G2. The number of cells producing acidic and neutral mucins, red blood cells and the level of antioxidant minerals, such as copper, magnesium, selenium and zinc, were significantly reduced in G2 and G3, but similar in G4 and G5 compared to G1. Naringin, especially at 200 mg/kg, was effective in reducing the number of pre-neoplastic lesions in rats exposed to DMH. Some of these effects may be due to reduction in cellular proliferation and tissue levels of iron together with the recovery of antioxidant mineral levels induced by this flavonoid.
Palabras clave
1,2-Dimethylhydrazine; 1,2-dimethylhydrazine; 8-OHdG; 8-hydroxy-2'-deoxyguanosine; AB; ACF; AgNORs; Alcian blue; DMH; EDS; Flavonoide; Large intestine; PAS; Pathology; Toxicology; Vv; X-ray energy dispersive spectroscopy; aberrant crypt foci; argyrophilic nucleolar organizing regions; periodic acid-schiff; volume density
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Lesiones Precancerosas
/
Neoplasias Colorrectales
/
Flavanonas
Límite:
Animals
Idioma:
En
Revista:
Food Chem Toxicol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Brasil