Short-term creatine supplementation does not reduce increased homocysteine concentration induced by acute exercise in humans.
Eur J Nutr
; 53(6): 1355-61, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-24318038
ABSTRACT
PURPOSE:
The purpose of the study is to evaluate the effects of creatine supplementation on homocysteine (Hcy) plasma levels after acute exercise in humans.METHODS:
Twenty-three young (under-20) soccer players were divided into 2 groups creatine (Cr)- and placebo (Pla)-supplemented groups. The supplementation was performed in double-blind controlled manner using creatine or placebo tablets with 0.3 g/kg during 7 days. Before and after 7 days of supplementation, the athletes performed an acute high-intensity sprint exercise (two consecutive running-based anaerobic sprint test protocol consisted in 6 × 35 m sprint with 10 s between them). Blood samples were collected before and after 7 days of supplementation as well as 0 and 1 h after exercise protocol.RESULTS:
Homocysteine concentration significant increased (P < 0.05) 1 h after acute exercise (18%). Acute exercise also decreased red blood cell S-adenosylmethionine (SAM) 30% with no changes in SAM/SAH ratio. Seven days of creatine supplementation were able to increase (P < 0.05) plasma creatine concentration (Pla 130.1 ± 21.7 vs Cr 1,557.2 ± 220.3 µmol/L) as well as decrease (P < 0.05) plasma guanidinoacetic acid (33%). Controversially, creatine supplementation did not change Hcy plasma level after 7-day supplementation (Pla 6.9 ± 0.2 vs Cr 7.2 ± 0.2 µmol/L) or after acute exercise (Pla 8.2 ± 0.3 vs Cr 8.4 ± 0.3 µmol/L). No changes in plasma vitamin B12 and folate as well as cysteine and methionine were found.CONCLUSIONS:
Seven days of creatine supplementation does not avoid increased plasma Hcy induced by acute sprint exercise in humans.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ejercicio Físico
/
Suplementos Dietéticos
/
Creatina
/
Conducta Alimentaria
/
Homocisteína
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Nutr
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
2014
Tipo del documento:
Article