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Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.
Li, Shuzhao; Rouphael, Nadine; Duraisingham, Sai; Romero-Steiner, Sandra; Presnell, Scott; Davis, Carl; Schmidt, Daniel S; Johnson, Scott E; Milton, Andrea; Rajam, Gowrisankar; Kasturi, Sudhir; Carlone, George M; Quinn, Charlie; Chaussabel, Damien; Palucka, A Karolina; Mulligan, Mark J; Ahmed, Rafi; Stephens, David S; Nakaya, Helder I; Pulendran, Bali.
Afiliación
  • Li S; 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3].
  • Rouphael N; 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3].
  • Duraisingham S; 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3].
  • Romero-Steiner S; Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Presnell S; 1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
  • Davis C; 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Schmidt DS; Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Johnson SE; Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Milton A; Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Rajam G; Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Kasturi S; 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
  • Carlone GM; Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Quinn C; 1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
  • Chaussabel D; 1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
  • Palucka AK; Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
  • Mulligan MJ; 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Geor
  • Ahmed R; 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.
  • Stephens DS; 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Nakaya HI; 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Pulendran B; 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
Nat Immunol ; 15(2): 195-204, 2014 Feb.
Article en En | MEDLINE | ID: mdl-24336226
ABSTRACT
Many vaccines induce protective immunity via antibodies. Systems biology approaches have been used to determine signatures that can be used to predict vaccine-induced immunity in humans, but whether there is a 'universal signature' that can be used to predict antibody responses to any vaccine is unknown. Here we did systems analyses of immune responses to the polysaccharide and conjugate vaccines against meningococcus in healthy adults, in the broader context of published studies of vaccines against yellow fever virus and influenza virus. To achieve this, we did a large-scale network integration of publicly available human blood transcriptomes and systems-scale databases in specific biological contexts and deduced a set of transcription modules in blood. Those modules revealed distinct transcriptional signatures of antibody responses to different classes of vaccines, which provided key insights into primary viral, protein recall and anti-polysaccharide responses. Our results elucidate the early transcriptional programs that orchestrate vaccine immunity in humans and demonstrate the power of integrative network modeling.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacunas Meningococicas / Biología de Sistemas / Infecciones Meningocócicas / Neisseria meningitidis Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2014 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacunas Meningococicas / Biología de Sistemas / Infecciones Meningocócicas / Neisseria meningitidis Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2014 Tipo del documento: Article