[The standardization of diagnostic of paroxysmal night hemoglobinuria cytometry].
Klin Lab Diagn
; (7): 54-8, 2013 Jul.
Article
en Ru
| MEDLINE
| ID: mdl-24341193
ABSTRACT
The flow cytometry becomes a more and more largely applied technique. However, the sufficient novelty of technique has no worked-out standards of diagnostic of many diseases. The lacking of external control of quality promotes development of large variety of approaches to diagnostic of diseases and impossibility to compare the study results from different laboratories. The paroxysmal night hemoglobinuria is an acquired clonal disease characterized by proliferation of stem cells with partial or total loss of expression of glykosylphosphosphatidyl inositol anchor needed to conjugate a number of surface proteins. The flow cytometry is a basic technique of detection and monitoring of clone of paroxysmal night hemoglobinuria. The article presents the results of paroxysmal night hemoglobinuria testing of 8 patients in 6 independent laboratories using flow cytometry by standard protocol recommended by the International society of clinical cytometrists (ICCS).
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Citometría de Flujo
/
Hemoglobinuria Paroxística
Tipo de estudio:
Diagnostic_studies
/
Guideline
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Klin Lab Diagn
Asunto de la revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Año:
2013
Tipo del documento:
Article