Highly selective gem-difluoroallylation of organoborons with bromodifluoromethylated alkenes catalyzed by palladium.
J Am Chem Soc
; 136(4): 1230-3, 2014 Jan 29.
Article
en En
| MEDLINE
| ID: mdl-24417183
ABSTRACT
A first example of Pd-catalyzed gem-difluoroallylation of organoborons using 3-bromo-3,3-difluoropropene (BDFP) in high efficiency with high α/γ-substitution regioselectivity has been developed. The reaction can also be extended to substituted BDFPs and has advantages of low catalyst loading (0.8 to 0.01 mol %), broad substrate scope, and excellent functional group compatibility, thus providing a facile route for practical application in drug discovery and development.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
/
Paladio
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Compuestos de Boro
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Alquenos
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Hidrocarburos Halogenados
Idioma:
En
Revista:
J Am Chem Soc
Año:
2014
Tipo del documento:
Article
País de afiliación:
China