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Missense variant in TREML2 protects against Alzheimer's disease.
Benitez, Bruno A; Jin, Sheng Chih; Guerreiro, Rita; Graham, Rob; Lord, Jenny; Harold, Denise; Sims, Rebecca; Lambert, Jean-Charles; Gibbs, J Raphael; Bras, Jose; Sassi, Celeste; Harari, Oscar; Bertelsen, Sarah; Lupton, Michelle K; Powell, John; Bellenguez, Celine; Brown, Kristelle; Medway, Christopher; Haddick, Patrick C G; van der Brug, Marcel P; Bhangale, Tushar; Ortmann, Ward; Behrens, Tim; Mayeux, Richard; Pericak-Vance, Margaret A; Farrer, Lindsay A; Schellenberg, Gerard D; Haines, Jonathan L; Turton, Jim; Braae, Anne; Barber, Imelda; Fagan, Anne M; Holtzman, David M; Morris, John C; Williams, Julie; Kauwe, John S K; Amouyel, Philippe; Morgan, Kevin; Singleton, Andy; Hardy, John; Goate, Alison M; Cruchaga, Carlos.
Afiliación
  • Benitez BA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Jin SC; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Guerreiro R; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Graham R; Diagnostic Discovery Department, Genentech Inc, South San Francisco, CA, USA.
  • Lord J; Human Genetics, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK.
  • Harold D; Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
  • Sims R; Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
  • Lambert JC; Inserm, Lille, France; Universite Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
  • Gibbs JR; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Bras J; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
  • Sassi C; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Harari O; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Bertelsen S; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Lupton MK; Institute of Psychiatry, King's College London, London, UK.
  • Powell J; Institute of Psychiatry, King's College London, London, UK.
  • Bellenguez C; Inserm, Lille, France; Universite Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
  • Brown K; Human Genetics, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK.
  • Medway C; Human Genetics, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK.
  • Haddick PC; Diagnostic Discovery Department, Genentech Inc, South San Francisco, CA, USA.
  • van der Brug MP; Diagnostic Discovery Department, Genentech Inc, South San Francisco, CA, USA.
  • Bhangale T; Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, CA, USA.
  • Ortmann W; Human Genetics Department, Genentech Inc, South San Francisco, CA, USA.
  • Behrens T; Human Genetics Department, Genentech Inc, South San Francisco, CA, USA.
  • Mayeux R; Department of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
  • Pericak-Vance MA; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA; Dr John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA.
  • Farrer LA; Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA, USA; Department of Biomedical Genetics, Boston University Schools of Medicine and Public Health, Boston, MA, USA; Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA,
  • Schellenberg GD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Haines JL; Department of Molecular Physiology and Biophysics, Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA.
  • Turton J; Human Genetics, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK.
  • Braae A; Human Genetics, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK.
  • Barber I; Human Genetics, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK.
  • Fagan AM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
  • Holtzman DM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Cen
  • Morris JC; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope
  • Williams J; Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
  • Kauwe JS; Department of Biology, Brigham Young University, Provo, UT, USA.
  • Amouyel P; Inserm, Lille, France; Universite Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
  • Morgan K; Human Genetics, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK.
  • Singleton A; Human Genetics Department, Genentech Inc, South San Francisco, CA, USA.
  • Hardy J; Human Genetics Department, Genentech Inc, South San Francisco, CA, USA.
  • Goate AM; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Cen
  • Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA; Universite Lille 2, Lille, France. Electronic address: cruchagac@psychiatry.wustl.edu.
Neurobiol Aging ; 35(6): 1510.e19-26, 2014 Jun.
Article en En | MEDLINE | ID: mdl-24439484
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Variación Genética / Receptores Inmunológicos / Mutación Missense / Estudio de Asociación del Genoma Completo / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Neurobiol Aging Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Variación Genética / Receptores Inmunológicos / Mutación Missense / Estudio de Asociación del Genoma Completo / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Neurobiol Aging Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos