A novel synthetic dibenzocyclooctadiene lignan analog XLYF-104-6 attenuates lipopolysaccharide-induced inflammatory response in RAW264.7 macrophage cells and protects BALB/c mice from sepsis.

Gu, Chunping; Yu, Fang-Lin; Yu, Le; He, Xiao-Yang; Zhong, Desheng; He, Longgang; Lv, Longyun; Xie, Lan; Liu, Shuwen

Gu, Chunping; Yu, Fang-Lin; Yu, Le; He, Xiao-Yang; Zhong, Desheng; He, Longgang; Lv, Longyun; Xie, Lan; Liu, Shuwen.

Afiliación

Gu C; School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China.
Yu FL; Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China.
Yu L; School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China.
He XY; Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China.
Zhong D; School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China.
He L; School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China.
Lv L; School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China.
Xie L; Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China.
Liu S; School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China. Electronic address: liusw@smu.edu.cn.

Eur J Pharmacol ; 729: 22-9, 2014 Apr 15.

Article en En | MEDLINE | ID: mdl-24462571

Asunto(s)

Ciclooctanos/uso terapéutico; Mediadores de Inflamación/metabolismo; Lignanos/uso terapéutico; Lipopolisacáridos/toxicidad; Macrófagos/metabolismo; Sepsis/metabolismo; Sepsis/prevención & control; Animales; Antiinflamatorios/química; Antiinflamatorios/farmacología; Antiinflamatorios/uso terapéutico; Línea Celular; Ciclooctanos/química; Ciclooctanos/farmacología; Relación Dosis-Respuesta a Droga; Femenino; Mediadores de Inflamación/antagonistas & inhibidores; Lignanos/química; Lignanos/farmacología; Macrófagos/efectos de los fármacos; Masculino; Ratones; Ratones Endogámicos BALB C; Sepsis/inducido químicamente

Palabras clave

Anti-inflammatory drug; Aprotinin (Pubchem CID: 16130295); BAY 11-7082 (Pubchem CID: 5353431); DAPI (Pubchem CID: 2954); Dibenzocyclooctadiene lignin; G418 (Pubchem CID: 123865); Leupeptin (Pubchem CID: 72429); Lipopolysaccharide; Lipopolysaccharide (Pubchem CID: 11970143); MTT (Pubchem CID: 64965); NF-κB; PMSF (Pubchem CID: 4784); Pepstatin (Pubchem CID: 5478883); Sepsis; Sodium fluoride (Pubchem CID: 5235); iNOS expression and NO production

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lipopolisacáridos / Lignanos / Sepsis / Mediadores de Inflamación / Ciclooctanos / Macrófagos Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 2014 Tipo del documento: Article País de afiliación: China

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