Psoriasis associated with idiopathic CD4+ T-cell lymphopenia: a regulatory T-cell defect?
Br J Dermatol
; 171(1): 186-9, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24579866
ABSTRACT
Idiopathic CD4(+) lymphocytopenia (ICL) is a rare immunodeficiency syndrome of unknown origin for which the increased risks of opportunistic infections and of malignancies have been well established; however, skin dysimmune diseases, including psoriasis, have been scarcely reported up to now. We report herein the severe course of psoriasis in four patients with ICL, and show evidence for a defect in the skin recruitment of regulatory CD4(+) FoxP3(+) T cells. These data raise the apparent paradigm of the occurrence of a severe immunomediated disease together with a profound T-cell defect, a model that might also apply to other immune deficiencies associated with psoriasis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Psoriasis
/
Linfocitos T Reguladores
/
Linfocitopenia-T Idiopática CD4-Positiva
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Br J Dermatol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Francia