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The identification of novel 5'-amino gemcitabine analogs as potent RRM1 inhibitors.
Labroli, Marc A; Dwyer, Michael P; Shen, Ruichao; Popovici-Muller, Janeta; Pu, Qinglin; Wyss, Daniel; McCoy, Mark; Barrett, Dianah; Davis, Nicole; Seghezzi, Wolfgang; Shanahan, Frances; Taricani, Lorena; Beaumont, Maribel; Malinao, Maria-Christina; Parry, David; Guzi, Timothy J.
Afiliación
  • Labroli MA; Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: marc.labroli@merck.com.
  • Dwyer MP; Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA.
  • Shen R; Merck Research Laboratories, 33 Avenue Louis Pasteur, BMB-3, Boston, MA 02115, USA.
  • Popovici-Muller J; Merck Research Laboratories, 33 Avenue Louis Pasteur, BMB-3, Boston, MA 02115, USA.
  • Pu Q; Merck Research Laboratories, 33 Avenue Louis Pasteur, BMB-3, Boston, MA 02115, USA.
  • Wyss D; Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • McCoy M; Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Barrett D; Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Davis N; Merck Research Laboratories, 901 South California Avenue, Palo Alto, CA 94304, USA.
  • Seghezzi W; Merck Research Laboratories, 901 South California Avenue, Palo Alto, CA 94304, USA.
  • Shanahan F; Merck Research Laboratories, 901 South California Avenue, Palo Alto, CA 94304, USA.
  • Taricani L; Merck Research Laboratories, 901 South California Avenue, Palo Alto, CA 94304, USA.
  • Beaumont M; Merck Research Laboratories, 901 South California Avenue, Palo Alto, CA 94304, USA.
  • Malinao MC; Merck Research Laboratories, 901 South California Avenue, Palo Alto, CA 94304, USA.
  • Parry D; Merck Research Laboratories, 901 South California Avenue, Palo Alto, CA 94304, USA.
  • Guzi TJ; Merck Research Laboratories, 33 Avenue Louis Pasteur, BMB-3, Boston, MA 02115, USA.
Bioorg Med Chem ; 22(7): 2303-10, 2014 Apr 01.
Article en En | MEDLINE | ID: mdl-24588962
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Supresoras de Tumor / Desoxicitidina Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Supresoras de Tumor / Desoxicitidina Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article