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Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.
Walker, Sarah; Meisenberg, Cornelia; Bibby, Rachel A; Askwith, Trevor; Williams, Gareth; Rininsland, Frauke H; Pearl, Laurence H; Oliver, Antony W; El-Khamisy, Sherif; Ward, Simon; Atack, John R.
Afiliación
  • Walker S; Translational Drug Discovery Group, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK.
  • Meisenberg C; Wellcome Trust DNA Repair Group, Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK.
  • Bibby RA; Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, University of Sussex, Science Park Road, Brighton BN1 9RQ, UK.
  • Askwith T; Translational Drug Discovery Group, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK.
  • Williams G; Translational Drug Discovery Group, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK.
  • Rininsland FH; Gyrasol Technologies, 2029 Becker Drive, Lawrence, KS 66047, USA.
  • Pearl LH; Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, University of Sussex, Science Park Road, Brighton BN1 9RQ, UK.
  • Oliver AW; Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, University of Sussex, Science Park Road, Brighton BN1 9RQ, UK.
  • El-Khamisy S; Wellcome Trust DNA Repair Group, Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK; Mammalian Genome Stability Group, Kreb's Institute, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK. Electronic address: s.el-khamisy@sheffield.ac.uk.
  • Ward S; Translational Drug Discovery Group, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK. Electronic address: Simon.Ward@sussex.ac.uk.
  • Atack JR; Translational Drug Discovery Group, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK. Electronic address: J.Atack@sussex.ac.uk.
Anal Biochem ; 454: 17-22, 2014 Jun 01.
Article en En | MEDLINE | ID: mdl-24637157
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oligonucleótidos / Espectrometría de Fluorescencia / Hidrolasas Diéster Fosfóricas / Evaluación Preclínica de Medicamentos / Inhibidores Enzimáticos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Anal Biochem Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oligonucleótidos / Espectrometría de Fluorescencia / Hidrolasas Diéster Fosfóricas / Evaluación Preclínica de Medicamentos / Inhibidores Enzimáticos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Anal Biochem Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido