Sustained autoimmune mechanisms in dermatomyositis.

Greenberg, Steven A

Greenberg, Steven A.

Afiliación

Greenberg SA; Brigham and Women's Hospital, Department of Neurology, and Children's Hospital Informatics Program, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, USA.

J Pathol ; 233(3): 215-6, 2014 Jul.

Article en En | MEDLINE | ID: mdl-24687932

ABSTRACT

ABSTRACT

Dermatomyositis is an autoimmune disease predominantly affecting skin and muscle. Its poorly understood pathogenesis is increasingly being linked to the overproduction of type 1 interferon-inducible gene transcripts and proteins. Mechanisms have been identified by which chronic sustained accumulation of these proteins might occur and thereby injure tissue in dermatomyositis.

Asunto(s)

ARN Helicasas DEAD-box/metabolismo; Dermatomiositis/metabolismo; Inmunidad Innata; Fibras Musculares Esqueléticas/metabolismo; Transducción de Señal; Proteína 58 DEAD Box; Femenino; Humanos; Masculino; Receptores Inmunológicos

Palabras clave

dermatomyositis; innate immune system; type 1 interferon

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Fibras Musculares Esqueléticas / Dermatomiositis / ARN Helicasas DEAD-box / Inmunidad Innata Límite: Female / Humans / Male Idioma: En Revista: J Pathol Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos

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