Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF&#945;-mediated hepatotoxicity.

Fredriksson, Lisa; Wink, Steven; Herpers, Bram; Benedetti, Giulia; Hadi, Mackenzie; de  Bont, Hans; Groothuis, Geny; Luijten, Mirjam; Danen, Erik; de  Graauw, Marjo; Meerman, John; van  de Water, Bob

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

Fredriksson, Lisa; Wink, Steven; Herpers, Bram; Benedetti, Giulia; Hadi, Mackenzie; de Bont, Hans; Groothuis, Geny; Luijten, Mirjam; Danen, Erik; de Graauw, Marjo; Meerman, John; van de Water, Bob.

Afiliación

Fredriksson L; Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands.
Wink S; Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands.
Herpers B; Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands.
Benedetti G; Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands.
Hadi M; Division of Pharmacokinetics, Toxicology and Targeting, Department of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands.
de Bont H; Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands.
Groothuis G; Division of Pharmacokinetics, Toxicology and Targeting, Department of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands.
Luijten M; The National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.
Danen E; Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands.
de Graauw M; Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands.
Meerman J; Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands.
van de Water B; Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands b.water@lacdr.leidenuniv.nl.

Toxicol Sci ; 140(1): 144-59, 2014 Jul.

Article en En | MEDLINE | ID: mdl-24752500

Asunto(s)

Carbamazepina/toxicidad; Enfermedad Hepática Inducida por Sustancias y Drogas/etiología; Diclofenaco/toxicidad; Estrés Oxidativo/efectos de los fármacos; Factor de Necrosis Tumoral alfa/metabolismo; Animales; Apoptosis/efectos de los fármacos; Enfermedad Hepática Inducida por Sustancias y Drogas/genética; Enfermedad Hepática Inducida por Sustancias y Drogas/metabolismo; Sinergismo Farmacológico; Estrés del Retículo Endoplásmico/efectos de los fármacos; Perfilación de la Expresión Génica; Estudio de Asociación del Genoma Completo; Células Hep G2; Hepatocitos/efectos de los fármacos; Hepatocitos/metabolismo; Humanos; Ratones Endogámicos C57BL; Factor 2 Relacionado con NF-E2/metabolismo; Estrés Oxidativo/inmunología; Transcriptoma/efectos de los fármacos; Factor de Necrosis Tumoral alfa/toxicidad

Palabras clave

RNA interference; drug-induced liver injury; high content microscopy; transcriptomics

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carbamazepina / Diclofenaco / Factor de Necrosis Tumoral alfa / Estrés Oxidativo / Enfermedad Hepática Inducida por Sustancias y Drogas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Toxicol Sci Asunto de la revista: TOXICOLOGIA Año: 2014 Tipo del documento: Article

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