Alteration of T-cell subpopulations and lipid peroxidation in the blood of patients with vulvar non-neoplastic epithelial disorder.
Clin Exp Obstet Gynecol
; 41(2): 174-6, 2014.
Article
en En
| MEDLINE
| ID: mdl-24779246
ABSTRACT
OBJECTIVE:
To determine the relationship between vulvar non-neoplastic epithelial disorder and thymus-dependent lymphyocyte levels and lipid peroxidation. MATERIALS ANDMETHODS:
the authors measured the levels of CD3+, CD4+, CD8+, CD16+ T cell, and the concentration of superoxide dismutase (SOD) and malondialdehyde (MDA) in the blood of 62 patients with vulvar non-neoplastic epithelial disorder. A control group consisted of 30 normal women from the present hospitals.RESULTS:
The level of CD4+/CD8+ T-lymphocytes and SOD in the blood of the patients with vulvar non-neoplastic epithelial disorder was significantly lower than that in control subjects, but the level of MDA was higher as compared with normal women.CONCLUSION:
There is increased immune activation and lipid peroxidation in patients with vulvar non-neoplastic epithelial disorder, which could contribute to destruction of vulvar tissue.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vulva
/
Peroxidación de Lípido
/
Linfocitos T CD4-Positivos
/
Subgrupos de Linfocitos T
/
Linfocitos T CD8-positivos
/
Liquen Escleroso Vulvar
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Clin Exp Obstet Gynecol
Año:
2014
Tipo del documento:
Article