Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling.
Mech Dev
; 133: 117-25, 2014 Aug.
Article
en En
| MEDLINE
| ID: mdl-24854243
ABSTRACT
Hedgehog (Hh) acts as a morphogen to activate the transcription of diverse target genes via its downstream effector Cubitus interruptus (Ci). Currently, it is less understood how Ci recruits co-factors to activate transcription. Here we report that hyperplastic discs (hyd), an E3 ubiquitin ligase, can differentially regulate the transcriptional outputs of Hh signaling. We show that loss of Hyd activity caused upregulation of some, but not all of Hh target genes. Importantly, Hyd does not affect the stability of Ci. Our data suggest that Hyd differentially restrains the transcriptional activity of Ci via selective association with respective promoters.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas de Drosophila
/
Ubiquitina-Proteína Ligasas
/
Drosophila melanogaster
/
Proteínas Hedgehog
Límite:
Animals
Idioma:
En
Revista:
Mech Dev
Asunto de la revista:
EMBRIOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
China