[The impact of donor naive and memory T cell subsets on patient outcome following allogeneic stem cell transplantation: relationship between infused donor CD4+/CCR7+ T cell subsets and acute graft-versus-host disease]. / Impact de la composition du greffon sur le devenir des patients après une allogreffe de cellules souches hématopoïétiques: corrélation entre proportion des lymphocytes T CD4+ du greffon exprimant le CCR7 et la survenue d'une GVH aiguë
Pathol Biol (Paris)
; 62(3): 123-8, 2014 Jun.
Article
en Fr
| MEDLINE
| ID: mdl-24906571
ABSTRACT
In a previous prospective study on 62 patients who underwent an HLA-matched allogeneic stem cell transplantation, we have observed that proportion of donor-derived CCR7(+)/CD4(+) T cells in the graft provided a predictive indicator of acute GVHD without interfering on chronic GVHD and relapse rate. Here we present our results on a confirmatory cohort of 137 consecutive patients. Indeed patients who received more than 76% of CCR7(+)/CD4(+) T cells in the graft developed more often acute GVHD be it of low or high grade than those who did not. Determination of the CCR7(+)/CCR7(neg) ratio of CD4(+) T cells in the graft provides a predictive indicator of acute GVHD and could help to define strategies of partial selective T cell depleted transplantation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T CD4-Positivos
/
Subgrupos de Linfocitos T
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Trasplante de Médula Ósea
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Recuento de Linfocito CD4
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Trasplante de Células Madre de Sangre Periférica
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Enfermedad Injerto contra Huésped
/
Memoria Inmunológica
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
Fr
Revista:
Pathol Biol (Paris)
Año:
2014
Tipo del documento:
Article
País de afiliación:
Francia