Cortistatin is endogenous to the human intervertebral disc and exerts in vitro mitogenic effects on annulus cells and a downregulatory effect on TNF-&#945; expression.

Gruber, Helen E; Hoelscher, Gretchen L; Bethea, Synthia F; Menscher, Evan A; Ingram, Jane A; Templin, Megan A; Hanley, Edward N

Cortistatin is endogenous to the human intervertebral disc and exerts in vitro mitogenic effects on annulus cells and a downregulatory effect on TNF-α expression.

Gruber, Helen E; Hoelscher, Gretchen L; Bethea, Synthia F; Menscher, Evan A; Ingram, Jane A; Templin, Megan A; Hanley, Edward N.

Afiliación

Gruber HE; Department of Orthopaedic Surgery, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA. Electronic address: helen.gruber@carolinashealthcare.org.
Hoelscher GL; Department of Orthopaedic Surgery, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA.
Bethea SF; Department of Orthopaedic Surgery, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA.
Menscher EA; Department of Orthopaedic Surgery, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA.
Ingram JA; Department of Orthopaedic Surgery, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA.
Templin MA; Dickson Advanced Analytics, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA.
Hanley EN; Department of Orthopaedic Surgery, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA.

Spine J ; 14(12): 2995-3001, 2014 Dec 01.

Article en En | MEDLINE | ID: mdl-24912122

Asunto(s)

Antiinflamatorios/farmacología; Disco Intervertebral/efectos de los fármacos; Neuropéptidos/farmacología; Factor de Necrosis Tumoral alfa/metabolismo; Adulto; Anciano; Proliferación Celular; Células Cultivadas; Regulación hacia Abajo; Femenino; Humanos; Disco Intervertebral/citología; Disco Intervertebral/metabolismo; Masculino; Persona de Mediana Edad; Neuropéptidos/metabolismo; Factor de Necrosis Tumoral alfa/genética

Palabras clave

Cell proliferation; Cortistatin; Disc degeneration; Gene expression; Immunohistochemistry; TNF-alpha

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neuropéptidos / Factor de Necrosis Tumoral alfa / Disco Intervertebral / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Spine J Asunto de la revista: ORTOPEDIA Año: 2014 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google