Neuronal repair. Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke.
Science
; 344(6189): 1250-5, 2014 Jun 13.
Article
en En
| MEDLINE
| ID: mdl-24926013
ABSTRACT
The brain exhibits limited capacity for spontaneous restoration of lost motor functions after stroke. Rehabilitation is the prevailing clinical approach to augment functional recovery, but the scientific basis is poorly understood. Here, we show nearly full recovery of skilled forelimb functions in rats with large strokes when a growth-promoting immunotherapy against a neurite growth-inhibitory protein was applied to boost the sprouting of new fibers, before stabilizing the newly formed circuits by intensive training. In contrast, early high-intensity training during the growth phase destroyed the effect and led to aberrant fiber patterns. Pharmacogenetic experiments identified a subset of corticospinal fibers originating in the intact half of the forebrain, side-switching in the spinal cord to newly innervate the impaired limb and restore skilled motor function.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tractos Piramidales
/
Recuperación de la Función
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Rehabilitación de Accidente Cerebrovascular
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Corteza Motora
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Proteínas de la Mielina
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2014
Tipo del documento:
Article