Stimulation of ornithine decarboxylase activity by arginine vasopressin in the rat medullary thick ascending limb of Henle's loop.
J Endocrinol
; 120(2): 195-9, 1989 Feb.
Article
en En
| MEDLINE
| ID: mdl-2494281
ABSTRACT
The effect of arginine vasopressin (AVP) on rat renal ornithine decarboxylase (ODC) activity was investigated by a cytochemical technique optimized for use in the medullary thick ascending limb of Henle's loop (mTAL). Stimulation of ODC activity by AVP was confined to the mTAL. Peaks in enzyme activity in cultured rat renal segments occurred after tissue had been exposed to AVP for 3 or 8 min and these times of maximal stimulation did not change with the concentration of AVP. There was a dose-dependent response in ODC activity over the AVP concentration range 0.01 10 fmol/l. The ODC response to AVP was totally blocked by specific antiserum to AVP and reduced by 70% with the specific inhibitor to ODC, difluoromethyl ornithine.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ornitina Descarboxilasa
/
Arginina Vasopresina
/
Médula Renal
/
Túbulos Renales
/
Asa de la Nefrona
Límite:
Animals
Idioma:
En
Revista:
J Endocrinol
Año:
1989
Tipo del documento:
Article