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Expression of cyclooxygenase-2 and Bcl-2 in breast cancer and their relationship with triple-negative disease.
Sezgin Alikanoglu, Arsenal; Yildirim, Mustafa; Suren, Dinc; Yildiz, Mustafa; Kaya, Vildan; Donem Dilli, Utku; Sezer, Cem.
Afiliación
  • Sezgin Alikanoglu A; Antalya Education and Research Hospital, Department of Pathology, Antalya, Turkey.
J BUON ; 19(2): 430-4, 2014.
Article en En | MEDLINE | ID: mdl-24965402
PURPOSE: Carcinogenesis is a multistep process with many factors being involved. The aim of this study was to investigate the role of cyclooxygenase-2 (COX-2) and Bcl-2 expression in patients with triple-negative breast cancer (TNBC) and, also whether any differences exist between TNBC and non-TNBC patients in relation with these two parameters. METHODS: This study included 50 patients with pathologically diagnosed TNBC and followed up at the Medical Oncology Clinic of Antalya Education and Research Hospital between 2008 and 2010. Thirty non-TNBC patients composed the control group. COX-2 and Bcl-2 expression was immunohistochemically investigated in both patient groups. RESULTS: COX-2 expression was positive in 26 (86.7%) of non-TNBC and 18 (90%) of TNBC patients (p=0.722). Compared with non-TNBC, TNBC correlated with higher Bcl-2 expression (p=0.005). Of the non-TBNC patients 86.7% and 50% of TNBC patients showed Bcl-2 expression. When Bcl-2 and COX-2 expression were considered together, a significant difference was found between the two groups (p=0.021). CONCLUSION: This study showed that increased COX-2 expression correlated with Bcl-2 expression both in TNBC and non-TNBC patients. Analysis of coexpression of Bcl- 2 and COX-2 may be meaningful for deciding treatment strategies for TNBC. Treatment strategies targeting Bcl-2 and COX-2 seem to be promising for this aggressive disease with no specific treatment.
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-bcl-2 / Ciclooxigenasa 2 / Neoplasias de la Mama Triple Negativas Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: J BUON Asunto de la revista: NEOPLASIAS Año: 2014 Tipo del documento: Article País de afiliación: Turquía
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-bcl-2 / Ciclooxigenasa 2 / Neoplasias de la Mama Triple Negativas Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: J BUON Asunto de la revista: NEOPLASIAS Año: 2014 Tipo del documento: Article País de afiliación: Turquía