microManaging mitochondrial translation.

Nouws, Jessica; Shadel, Gerald S

Nouws, Jessica; Shadel, Gerald S.

Afiliación

Nouws J; Department of Pathology, Yale School of Medicine, New Haven, CT 06437, USA.
Shadel GS; Department of Pathology, Yale School of Medicine, New Haven, CT 06437, USA; Department of Genetics, Yale School of Medicine, New Haven, CT 06437, USA. Electronic address: gerald.shadel@yale.edu.

Cell ; 158(3): 477-8, 2014 Jul 31.

Article en En | MEDLINE | ID: mdl-25083863

RESUMEN

Regulation of gene expression in mammalian mitochondria by microRNAs is reported by Zhang et al. During muscle cell differentiation, localization of a miRNA is increased within mitochondria, where it interacts with Ago2 to selectively activate translation of mtDNA-encoded mRNAs. The findings represent a new mitochondrial regulatory pathway and a potentially powerful means to purposefully manipulate mtDNA expression.

Asunto(s)

Diferenciación Celular; MicroARNs/metabolismo; Mitocondrias/metabolismo; Mioblastos/metabolismo; Miocitos Cardíacos/metabolismo; Biosíntesis de Proteínas; Animales

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Biosíntesis de Proteínas / Diferenciación Celular / Miocitos Cardíacos / Mioblastos / MicroARNs / Mitocondrias Límite: Animals Idioma: En Revista: Cell Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos

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