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The sigma-1 receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) protects against newborn excitotoxic brain injury by stabilizing the mitochondrial membrane potential in vitro and inhibiting microglial activation in vivo.
Wegleiter, Karina; Hermann, Martin; Posod, Anna; Wechselberger, Karina; Stanika, Ruslan I; Obermair, Gerald J; Kiechl-Kohlendorfer, Ursula; Urbanek, Martina; Griesmaier, Elke.
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  • Wegleiter K; Department of Pediatrics II (Neonatology), Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria.
  • Hermann M; Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria.
  • Posod A; Department of Pediatrics II (Neonatology), Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria.
  • Wechselberger K; Department of Pediatrics II (Neonatology), Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria.
  • Stanika RI; Department of Physiology and Medical Physics, Innsbruck Medical University, Fritz-Pregl-Strasse 3, 6020 Innsbruck, Austria.
  • Obermair GJ; Department of Physiology and Medical Physics, Innsbruck Medical University, Fritz-Pregl-Strasse 3, 6020 Innsbruck, Austria.
  • Kiechl-Kohlendorfer U; Department of Pediatrics II (Neonatology), Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria.
  • Urbanek M; Department of Pediatrics II (Neonatology), Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria.
  • Griesmaier E; Department of Pediatrics II (Neonatology), Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria. Electronic address: Elke.Griesmaier@i-med.ac.at.
Exp Neurol ; 261: 501-9, 2014 Nov.
Article en En | MEDLINE | ID: mdl-25111531
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Receptores sigma / Microglía / Potencial de la Membrana Mitocondrial / Haloperidol Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Exp Neurol Año: 2014 Tipo del documento: Article País de afiliación: Austria
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Receptores sigma / Microglía / Potencial de la Membrana Mitocondrial / Haloperidol Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Exp Neurol Año: 2014 Tipo del documento: Article País de afiliación: Austria