Neuroimmune pathways in alcohol consumption: evidence from behavioral and genetic studies in rodents and humans.
Int Rev Neurobiol
; 118: 13-39, 2014.
Article
en En
| MEDLINE
| ID: mdl-25175860
ABSTRACT
Immune or brain proinflammatory signaling has been linked to some of the behavioral effects of alcohol. Immune signaling appears to regulate voluntary ethanol intake in rodent models, and ethanol intake activates the immune system in multiple models. This bidirectional link raises the possibility that consumption increases immune signaling, which in turn further increases consumption in a feed-forward cycle. Data from animal and human studies provide overlapping support for the involvement of immune-related genes and proteins in alcohol action, and combining animal and human data is a promising approach to systematically evaluate and nominate relevant pathways. Based on rodent models, neuroimmune pathways may represent unexplored, nontraditional targets for medication development to reduce alcohol consumption and prevent relapse. Peroxisome proliferator-activated receptor agonists are one class of anti-inflammatory medications that demonstrate antiaddictive properties for alcohol and other drugs of abuse. Expression of immune-related genes is altered in animals and humans following chronic alcohol exposure, and the regulatory influences of specific mRNAs, microRNAs, and activated cell types are areas of intense study. Ultimately, the use of multiple datasets combined with behavioral validation will be needed to link specific neuroimmune pathways to addiction vulnerability.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Consumo de Bebidas Alcohólicas
/
Neuroinmunomodulación
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Transducción de Señal
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Regulación de la Expresión Génica
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Conducta Adictiva
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Encefalitis
Límite:
Animals
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Humans
Idioma:
En
Revista:
Int Rev Neurobiol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos